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IL28B Polymorphism Genotyping


Test Information

Test Name: IL28B Polymorphism Genotyping

Performing Lab: Molecular Diagnostic

Turnaround Time: 14 days

Additional Interpretation: A single nucleotide polymorphism (SNP) (rs12979860) upstream of the IL28B gene has been correlated with a viral response to combination pegylated interferon/ribavirin therapy in Hepatitis C Virus (HCV) genotype-1 chronically infected individuals. The CC genotype, compared to the CT or TT genotypes, has been associated with a two-to-three-fold greater rate of Sustained Virologic Response (SVR) in HCV genotype 1 patients.

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Methodology: Allelic discrimination using PCR amplification and signal detection in a real-time PCR instrument. The reaction includes a pair of primers for amplifying the target region and an allele-specific, fluorescent dye-labeled probe for each allele of IL28B SNP. The allelic discrimination reaction is followed by data analysis using the instrument software.

CPT Code: 81479

 

 

Result Information

No Information Available

 

 

Specimen & Collection Information

Specimen Name: Whole blood

Container Type: Lavender Top (EDTA)

Special Handling: Refrigerate

Specimen Volume: 1.0 mL

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Specimen Transportation & Storage Information

Storage and Transport:Deliver the blood to the laboratory immediately after collection. Remote Locations : Do not spin the blood. Store refrigerated at 2-8ºC.